Article
Systemic and Intracranial Efficacy and Safety of Trastuzumab Deruxtecan in Patients With HER2-Mutant NSCLC Across Treatment Lines: Evidence From the TRACER/HERTras Real-World Cohort.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jul 2026
Illini Oliver, Hund Anna-Carina, Kopp Hans-Georg, Moskovitz Mor, Mountzios Giannis, Brueckl Wolfgang M, Früh Martin, Leßmann Marie-Elisabeth, Christopoulos Petros, Stenzinger Albrecht, Thomas Michael, Gillis Roni, Peled Nir, Acker Fabian, Addeo Alfredo, Charpidou Andriani, Grohé Christian, Hummel Horst-Dieter, Mauti Laetitia, Rothschild Sacha I, Schmid Sabine, Schumann Christian, Urban Damien, Wurm Robert, Ekman Simon, Skribek Marcus, Glanemann Franziska, Wiesweg Marcel, Ackermann Christoph Jakob, Agelaki Sofia, Hoffknecht Petra, Jakopović Marko, Kern Jens, König David, Kostenzer Katharina, Kropf-Sanchen Cornelia, Laack Eckart, Lang David, Nagl Laurenz, Pall Georg, Reck Martin, Kian Waleed, Allemann Anna T, Alt Jürgen, Araújo David, Bohnenberger Hanibal, Bokas Alexandros, Fabikan Hannah, Julie Krainer-Jacobs, Weinlinger Christoph, Johannes de Langen Adrianus, Fergadis Evangelos Georgios, Fischer Rieke, Fountzilas Elena, Froesch Patrizia, Frost Nikolaj, Griesinger Frank, Jordan Franziska, Karanikiotis Charisios, Kiesewetter Barbara, Korantzis Ippokratis, Machado Andrea Lopes, Economopoulou Panagiota, Pilz Arnold, Reimann Patrick, Rittmeyer Achim, Saad Akram, Samitas Konstantinos, Schulmann Karsten, Shah Riyaz, Stratmann Jan Alexander, Taghizadeh Hossein, Tammoscheit Kai, Tufman Amanda, Weber Jan-Phillip, Wöll Ewald, Valipour Arschang, Overbeck Tobias R, Hochmair Maximilian J
Abstract excerpt
INTRODUCTION: HER2 mutations define a distinct, therapeutically actionable subset of NSCLC. Trastuzumab deruxtecan (T-DXd) has demonstrated strong activity in clinical trials, but real-world data are limited. METHODS: We conducted a retrospective, multinational cohort study of patients with advanced HER2-mutant NSCLC treated with T-DXd outside clinical trials between August 2021 and January 2025 across 68 centers...
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