Datopotamab Deruxtecan in Advanced or Metastatic Non-Small Cell Lung Cancer With Actionable Genomic Alterations: Results From the Phase II TROPION-Lung05 Study.

doi:10.1200/JCO-24-01349

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Datopotamab Deruxtecan in Advanced or Metastatic Non-Small Cell Lung Cancer With Actionable Genomic Alterations: Results From the Phase II TROPION-Lung05 Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Apr 2025

Sands Jacob, Ahn Myung-Ju, Lisberg Aaron, Cho Byoung Chul, Blumenschein George, Shum Elaine, Pons Tostivint Elvire, Goto Yasushi, Yoh Kiyotaka, Heist Rebecca, Shimizu Junichi, Lee Jong-Seok, Baas Paul, Planchard David, Pérol Maurice, Felip Enriqueta, Su Wu-Chou, Zebger-Gong Hong, Lan Lan, Liu Chelsea, Howarth Paul, Chiaverelli Rachel, Paz-Ares Luis

Abstract excerpt

PURPOSE: Datopotamab deruxtecan (Dato-DXd) is a trophoblast cell-surface antigen-2-directed antibody-drug conjugate with a highly potent topoisomerase I inhibitor payload. The TROPION-Lung05 phase II trial (ClinicalTrials.gov identifier: NCT04484142) evaluated the safety and clinical activity of Dato-DXd in patients with advanced/metastatic non-small cell lung cancer (NSCLC) with actionable genomic alterations...

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PMID: 39761483
DOI: 10.1200/JCO-24-01349
PMCID: PMC11949215

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