Final Analysis Results and Patient-Reported Outcomes From DESTINY-Lung02-A Dose-Blinded, Randomized, Phase 2 Study of Trastuzumab Deruxtecan in Patients With HER2-Mutant Metastatic NSCLC.

doi:10.1016/j.jtho.2025.07.129

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Final Analysis Results and Patient-Reported Outcomes From DESTINY-Lung02-A Dose-Blinded, Randomized, Phase 2 Study of Trastuzumab Deruxtecan in Patients With HER2-Mutant Metastatic NSCLC.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Dec 2025

Jänne Pasi A, Goto Yasushi, Kubo Toshio, Ninomiya Kiichiro, Kim Sang-We, Planchard David, Ahn Myung-Ju, Smit Egbert, Johannes de Langen Adrianus, Pérol Maurice, Pons-Tostivint Elvire, Novello Silvia, Hayashi Hidetoshi, Shimizu Junichi, Kim Dong-Wan, Pereira Kaline, Cheng Fu-Chih, Taguchi Ayumi, Cheng Yingkai, Dunton Kyle, Ali Ahmed, Goto Koichi

Abstract excerpt

INTRODUCTION: Trastuzumab deruxtecan (T-DXd) demonstrated strong and durable responses in patients with previously treated HER2 (ERBB2) mutant (HER2m) metastatic NSCLC (mNSCLC) in the DESTINY-Lung02 primary analysis (December 23, 2022, data cutoff). This final analysis evaluated T-DXd efficacy and safety after 8 additional months of follow-up, including clinically relevant subgroups and patient-reported outcomes....

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PMID: 40749900
DOI: 10.1016/j.jtho.2025.07.129

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