Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human-induced pluripotent stem cell-derived neural stem/progenitor cell ex vivo gene therapy with synaptic organizer CPTX for spinal cord injury

15 Feb 2024

Abstract excerpt

The transplantation of neural stem/progenitor cells (NS/PCs) derived from human induced pluripotent stem cells (hiPSCs) has shown promise in spinal cord injury (SCI) model animals. Establishing a functional synaptic connection between the transplanted and host neurons is crucial for motor function recovery. To boost therapeutic outcomes, we developed an ex vivo gene therapy aimed at promoting synapse formation by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve injury and regeneration
Share to Pluripotent Stem Cells Research
Share to Spinal Cord Injury Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38366597
DOI: 10.1016/j.stemcr.2024.01.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human-induced pluripotent stem cell-derived neural stem/progenitor cell ex vivo gene therapy with synaptic organizer CPTX for spinal cord injuryPMID 38366597Read ↗

Neuromesodermal Progenitors Advance Network Formation of Spinal Neurons and Support Cells in Neural Ribbons <i>In Vitro</i> and Unprotected Survival in a Rat Subacute Contusion ModelSemantic proximity Read ↗

HiPSC-Derived NSCs Effectively Promote The Functional Recovery of Acute Spinal Cord Injury in MiceSemantic proximity Read ↗

Development and Characterization of Self-Tracing Neural Progenitor Cells for Mapping Their Synaptic Integration into Endogenous Neural NetworksSemantic proximity Read ↗

Human spinal interneurons repair the injured spinal cord through synaptic integrationSemantic proximity Read ↗

Activation of Endogenous Spinal Cord Stem Cell Mediates Recovery Induced by Olfactory Ensheathing Cell Transplantation Following Spinal Cord InjurySemantic proximity Read ↗

Neural tissue engineering using embryonic and induced pluripotent stem cellsSemantic proximity Read ↗

Analysis of astrocyte progenitors derived from human induced pluripotent stem cells <i>in vitro</i> and following transplantation into the intact spinal cordSemantic proximity Read ↗

Human Neural Stem Cells Differentiate and Integrate, Innervating Implanted zQ175 Huntington’s Disease Mouse StriatumSemantic proximity Read ↗

Human microphysiological model of dorsal root ganglion-spinal cord dorsal horn circuitry recapitulates opioid induced effectsSemantic proximity Read ↗

Grafted human induced pluripotent stem cells improve the outcome of spinal cord injury: modulation of the lesion microenvironmentSemantic proximity Read ↗

Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats.Semantic proximity Read ↗

Conversion of Human Induced Pluripotent Stem Cells (iPSCs) into Functional Spinal and Cranial Motor Neurons Using PiggyBac VectorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.