Article
Deep learning prediction of BRAF-RAS gene expression signature identifies noninvasive follicular thyroid neoplasms with papillary-like nuclear features.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2021
Dolezal James M, Trzcinska Anna, Liao Chih-Yi, Kochanny Sara, Blair Elizabeth, Agrawal Nishant, Keutgen Xavier M, Angelos Peter, Cipriani Nicole A, Pearson Alexander T
Abstract excerpt
Noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) are follicular-patterned thyroid neoplasms defined by nuclear atypia and indolent behavior. They harbor RAS mutations, rather than BRAFV600E mutations as is observed in papillary thyroid carcinomas with extensive follicular growth. Reliably identifying NIFTPs aids in safe therapy de-escalation, but has proven to be challenging...
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