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Article

Real-time evaluation of signal accuracy in wastewater surveillance of pathogens with high rates of mutation.

Scientific reports - 14 Feb 2024

Thakali Ocean, Mercier Élisabeth, Eid Walaa, Wellman Martin, Brasset-Gorny Julia, Overton Alyssa K, Knapp Jennifer J, Manuel Douglas, Charles Trevor C, Goodridge Lawrence, Arts Eric J, Poon Art F Y, Brown R Stephen, Graber Tyson E, Delatolla Robert, DeGroot Christopher T

Abstract excerpt

Wastewater surveillance of coronavirus disease 2019 (COVID-19) commonly applies reverse transcription-quantitative polymerase chain reaction (RT-qPCR) to quantify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA concentrations in wastewater over time. In most applications worldwide, maximal sensitivity and specificity of RT-qPCR has been achieved, in part, by monitoring two or more genomic loci of...

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Identifiers

PMID: 38355869
DOI: 10.1038/s41598-024-54319-y
PMCID: PMC10866965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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