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scRNA-seq revealed high stemness epithelial malignant cell clusters and prognostic models of lung adenocarcinoma

14 Feb 2024

Abstract excerpt

Lung adenocarcinoma (LUAD) is one of the sole causes of death in lung cancer patients. This study combined with single-cell RNA-seq analysis to identify tumor stem-related prognostic models to predict the prognosis of lung adenocarcinoma, chemotherapy agents, and immunotherapy efficacy. mRNA expression-based stemness index (mRNAsi) was determined by One Class Linear Regression (OCLR). Differentially expressed...

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PMID: 38355636
DOI: 10.1038/s41598-024-54135-4

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