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Nucleoprotein reassortment enhanced transmissibility of H3 1990.4.a clade influenza A virus in swine

14 Feb 2024

Abstract excerpt

The increased detection of H3 C-IVA (1990.4.a) clade influenza A viruses (IAVs) in US swine in 2019 was associated with a reassortment event to acquire an H1N1pdm09 lineage nucleoprotein (pdmNP) gene, replacing a TRIG lineage NP (trigNP). We hypothesized that acquiring the pdmNP conferred a selective advantage over prior circulating H3 viruses with a trigNP. To investigate the role of NP reassortment in...

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PMID: 38353535
DOI: 10.1128/jvi.01703-23

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