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Inhibition of AMPK activation in Echinococcus granulosus sensu stricto limits the parasite's glucose metabolism and survival.

Antimicrobial agents and chemotherapy - 6 Mar 2024

Yan Mingzhi, Liu Hui, Su Yansen, Bi Xiaojuan, Yang Ning, Lin Renyong, Lü Guodong

Abstract excerpt

Cystic echinococcosis (CE) is a zoonotic parasitic disease caused by larvae of the Echinococcus granulosus sensu lato (s.l.) cluster. There is an urgent need to develop new drug targets and drug molecules to treat CE. Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a serine/threonine protein kinase consisting of α, β, and γ subunits, plays a key role in the regulation of energy metabolism. However,...

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PMID: 38349157
DOI: 10.1128/aac.01202-23
PMCID: PMC10916388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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