Article
Translating next generation sequencing to practice: opportunities and necessary steps.
Molecular oncology - 1 Aug 2013
Kamalakaran Sitharthan, Varadan Vinay, Janevski Angel, Banerjee Nilanjana, Tuck David, McCombie W Richard, Dimitrova Nevenka, Harris Lyndsay N
Abstract excerpt
Next-generation sequencing (NGS) approaches for measuring RNA and DNA benefit from greatly increased sensitivity, dynamic range and detection of novel transcripts. These technologies are rapidly becoming the standard for molecular assays and represent huge potential value to the practice of oncology. However, many challenges exist in the transition of these technologies from research application to clinical...
Topics
- DNA Copy Number Variations
- Genomics
- High-Throughput Nucleotide Sequencing
- Humans
- Male
- Mutation
- Neoplasms
- Sequence Analysis, DNA