Article
Feasible diet and circadian interventions reduce in vivo progression of FLT3-ITD-positive acute myeloid leukemia.
Cancer medicine - 1 Jan 2024
Rodriguez Megan, Fekry Baharan, Murphy Brianna, Figueroa Mary, Cheng Tiewei, Raber Margaret, Wartenberg Lisa, Bell Donna, Triche Lisa, Crawford Karla, Ma Huaxian, Allton Kendra, Ahmed Ruwaida, Tran Jaime, Ranieri Christine, Konopleva Marina, Barton Michelle, Nunez Cesar, Eckel-Mahan Kristin, Chandra Joya
Abstract excerpt
BACKGROUND: Acute myeloid leukemia (AML) with an internal tandem duplication in the fms-like tyrosine kinase receptor 3 gene (FLT3-ITD) is associated with poor survival, and few studies have examined the impact of modifiable behaviors, such as nutrient quality and timing, in this subset of acute leukemia. METHODS: The influence of diet composition (low-sucrose and/or low-fat diets) and timing of diet were tested...
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