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Article

T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution.

Journal of experimental & clinical cancer research : CR - 2 Feb 2024

Yang Wenhui, Liu Shimao, Mao Mengyun, Gong Yandong, Li Xiaohui, Lei Tianyu, Liu Chao, Wu Shikai, Hu Qinyong

Abstract excerpt

Tumor-infiltrating T cells recognize, attack, and clear tumor cells, playing a central role in antitumor immune response. However, certain immune cells can impair this response and help tumor immune escape. Therefore, exploring the factors that influence T-cell infiltration is crucial to understand tumor immunity and improve therapeutic effect of cancer immunotherapy. The use of single-cell RNA sequencing...

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Source

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Identifiers

PMID: 38303018
DOI: 10.1186/s13046-024-02960-w
PMCID: PMC10835979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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