Vacuoles in bone marrow progenitors: VEXAS syndrome and beyond.

doi:10.1016/S2352-3026(23)00375-7

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Article

Vacuoles in bone marrow progenitors: VEXAS syndrome and beyond.

The Lancet. Haematology - 1 Feb 2024

Lacombe Valentin, Hadjadj Jérome, Georgin-Lavialle Sophie, Lavigne Christian, Geneviève Franck, Kosmider Olivier

Abstract excerpt

The presence of vacuoles in myeloid and erythroid progenitor cells in bone marrow aspirates is a key feature of vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome. The mere observation of vacuolated progenitor cells is not specific to VEXAS syndrome; in this Viewpoint, we point out the causes to be considered in this situation. Vacuoles, in particular, can be observed in individuals with...

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PMID: 38302223
DOI: 10.1016/S2352-3026(23)00375-7

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