Article
The Clinical Validity of Urinary Pellet DNA Monitoring for the Diagnosis of Recurrent Bladder Cancer.
The Journal of molecular diagnostics : JMD - 1 Apr 2024
Abe Masakazu, Hiraki Hayato, Tsuyukubo Takashi, Ono Sadahide, Maekawa Shigekatsu, Tamura Daichi, Yashima-Abo Akiko, Kato Renpei, Fujisawa Hiromitsu, Iwaya Takeshi, Park Woong-Yang, Idogawa Masashi, Tokino Takashi, Obara Wataru, Nishizuka Satoshi S
Abstract excerpt
The aim of this study was to evaluate the clinical validity of monitoring urine pellet DNA (upDNA) of bladder cancer (BC) by digital PCR (dPCR) as a biomarker for early recurrence prediction, treatment efficacy evaluation, and no-recurrence corroboration. Tumor panel sequencing was first performed to select patient-unique somatic mutations to monitor both upDNA and circulating tumor DNA (ctDNA) by dPCR. For...
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