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Article

Genetically proxied low-density lipoprotein cholesterol lowering via PCSK9-inhibitor drug targets and risk of congenital malformations.

European journal of preventive cardiology - 3 Jun 2024

Ardissino Maddalena, Slob Eric A W, Reddy Rohin K, Morley Alec P, Schuermans Art, Hill Phoebe, Williamson Catherine, Honigberg Michael C, de Marvao Antonio, Ng Fu Siong

Abstract excerpt

AIMS: Current guidelines advise against the use of lipid-lowering drugs during pregnancy. This is based only on previous observational evidence demonstrating an association between statin use and congenital malformations, which is increasingly controversial. In the absence of clinical trial data, we aimed to use drug-target Mendelian randomization to model the potential impact of fetal LDL-lowering, overall and...

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Share to Abnormalities, Drug-Induced
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38294056
DOI: 10.1093/eurjpc/zwad402
PMCID: PMC11144467

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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