Article
HLA-B gene methylation and expression in Behçet's syndrome: a potential role of epigenetics in the pathogenesis.
Clinical and experimental rheumatology - 1 Oct 2024
Özkılınç Önen Merve, Everest Elif, Demirci Turna, Köprülü Şen Pelinsu, Kızıltepe Kısakesen Esra, Özgüler Yeşim, Esatoğlu Sinem Nihal, Seyahi Emire, Tahir Turanlı Eda
Abstract excerpt
OBJECTIVES: The HLA-B51 locus has the strongest association with Behçet's syndrome (BS). The presence of a CpG island in the HLA-B gene led us to examine the role of epigenetic regulation in BS. METHODS: HLA-B51 genotyping was performed via sequence-specific PCR in 15 index familial BS cases, 17 affected relatives, 26 unaffected relatives, 46 sporadic BS cases, and 41 healthy controls. HLA-B methylation level was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.