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Infectious bursal disease virus VP5 triggers host shutoff in a transcription-dependent manner

30 Jan 2024

Abstract excerpt

ABSTRACT Viruses have evolved intricate mechanisms to evade host antiviral responses and exploit cellular resources by manipulating the expression profile of host genes. During infection, viruses encode proteins with shutoff activity to globally inhibit host protein synthesis, which is an effective strategy for immune evasion. In this study, compelling evidence shows that infectious bursal disease virus (IBDV)...

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PMID: 38289089
DOI: 10.1128/mbio.03433-23

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