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Article

Molecular landscape of the interleukin-40 encoding gene, C17orf99, in patients with acute myeloid leukemia.

Gene - 30 Apr 2024

Bashi Mustafa A, Ad'hiah Ali H

Abstract excerpt

Acute myeloid leukemia (AML) is a malignant hematological disorder in which aberrant cytokine signaling and inflammation play a role in disease initiation and progression. Interleukin-40 (IL-40) is a novel cytokine encoded by the chromosome 17 open reading frame 99 (C17orf99) gene. This cytokine is involved in mediating inflammation but its biological significance in the pathogenesis of AML has not been...

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PMID: 38286266
DOI: 10.1016/j.gene.2024.148214

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