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Article

IKAROS expression drives the aberrant metabolic phenotype of macrophages in chronic HIV infection.

Clinical immunology (Orlando, Fla.) - 1 Mar 2024

Vittori Cecilia, Faia Celeste, Wyczechowska Dorota, Trauth Amber, Plaisance-Bonstaff Karlie, Meyaski-Schluter Mary, Reiss Krzysztof, Peruzzi Francesca

Abstract excerpt

The increased risk for acquiring secondary illnesses in people living with HIV (PLWH) has been associated with immune dysfunction. We have previously found that circulating monocytes from PLWH display a trained phenotype. Here, we evaluated the metabolic profile of these cells and found increased mitochondrial respiration and glycolysis of monocyte-derived macrophages (MDMs) from PLWH. We additionally found that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38286172
DOI: 10.1016/j.clim.2024.109915
PMCID: PMC10922842

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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