Persistence of Innate Immune Pathways in Late Stage Human Bacterial and Fungal Keratitis: Results from a Comparative Transcriptome Analysis

Abstract excerpt

Microbial keratitis (MK) is a major cause of blindness worldwide. Despite adequate antimicrobial treatment, tissue damage can ensue. We compared the human corneal transcriptional profile in late stage MK to normal corneal tissue to identify pathways involved in pathogenesis. Total RNA from MK tissue and normal cadaver corneas was used to determine transcriptome profiles with Illumina HumanHT-12 v4 beadchips. We...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
• Share to Ocular Diseases and Behçet’s Syndrome
• Share to Ocular Infections and Treatments