Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The m6A demethylase FTO targets POLQ to promote ccRCC cell proliferation and genome stability maintenance

25 Jan 2024

Abstract excerpt

Abstract Background and aim As the first identified m6A demethylase, FTO has been implicated in the progression of various cancers. However, the specific mechanism of FTO in clear cell renal cell carcinoma (ccRCC) remains incompletely understood. In this study, we aimed to explore the potential molecular mechanisms influencing the progression of ccRCC. Methods We initially assessed the expression of FTO in tumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA modifications and cancer
Share to Viral-associated cancers and disorders

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38270643
DOI: 10.1007/s00432-023-05541-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The m6A demethylase FTO targets POLQ to promote ccRCC cell proliferation and genome stability maintenancePMID 38270643Read ↗

Exploring the role of m6A modification in cancerSemantic proximity Read ↗

Lysine-specific demethylase 2A gene expression in clear cell renal cell carcinoma and its clinical significanceSemantic proximity Read ↗

RNA N6-methyladenosine demethylase FTO targets MOXD1 promoting the malignant phenotype of gastric cancer.Semantic proximity Read ↗

NT5M-mediated R-loop stabilization promotes clear cell renal cell carcinoma progressionSemantic proximity Read ↗

Transcriptome-wide Landscape of RNA Modification N6-Methyladenosine in Chromophobe Renal Cell CarcinomaSemantic proximity Read ↗

The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cellsSemantic proximity Read ↗

Reduction in H3K4me patterns due to aberrant expression of methyltransferases and demethylases in renal cell carcinoma: prognostic and therapeutic implicationsSemantic proximity Read ↗

m6A Demethylase FTO regulates nasopharyngeal carcinoma invasion, migrationSemantic proximity Read ↗

PRMT1 is a critical dependency in clear cell renal cell carcinoma through its role in post-transcriptional regulation of DNA damage response genesSemantic proximity Read ↗

A proteogenomic analysis of clear cell renal cell carcinoma in a Chinese populationSemantic proximity Read ↗

Lysine methyltransferase 5C increases the proliferation and metastatic abilities of clear cell renal cell carcinoma via aerobic glycolysisSemantic proximity Read ↗

The Deubiquitinase USP2 Inhibits Clear Cell Renal Cell Carcinoma by Activating the p53 Signaling Pathway and Inducing FerroptosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.