Article
Association study of EP1 gene polymorphisms with suicide completers in the Japanese population.
Progress in neuro-psychopharmacology & biological psychiatry - 1 Jun 2011
Cui Huxing, Supriyanto Irwan, Sasada Tohru, Shiroiwa Kyoichi, Fukutake Masaaki, Shirakawa Osamu, Asano Migiwa, Ueno Yasuhiro, Nagasaki Yasushi, Hishimoto Akitoyo
Abstract excerpt
BACKGROUND: Both environmental and genetic factors have been reported to be involved in suicidal behaviors. Considerable evidence indicates that impulsive aggression is one of the important risk factors that contribute to suicide. A recent study has shown that prostaglandin E2 type 1 receptor (EP1) signaling regulates impulsive-aggressive behaviors in mice under both social and environmental stresses. To test the...
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