Enrichment of Bacteroides fragilis and enterotoxigenic Bacteroides fragilis in CpG island methylator phenotype-high colorectal carcinoma.

doi:10.1016/j.cmi.2024.01.013

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Article

Enrichment of Bacteroides fragilis and enterotoxigenic Bacteroides fragilis in CpG island methylator phenotype-high colorectal carcinoma.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 May 2024

Takashima Yasutoshi, Kawamura Hidetaka, Okadome Kazuo, Ugai Satoko, Haruki Koichiro, Arima Kota, Mima Kosuke, Akimoto Naohiko, Nowak Jonathan A, Giannakis Marios, Garrett Wendy S, Sears Cynthia L, Song Mingyang, Ugai Tomotaka, Ogino Shuji

Abstract excerpt

OBJECTIVES: Data support that enterotoxigenic Bacteroides fragilis (ETBF) harbouring the Bacteroides fragilis toxin (bft) gene may promote colorectal tumourigenesis through the serrated neoplasia pathway. We hypothesized that ETBF may be enriched in colorectal carcinoma subtypes with high-level CpG island methylator phenotype (CIMP-high), BRAF mutation, and high-level microsatellite instability (MSI-high)....

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Identifiers

PMID: 38266708
DOI: 10.1016/j.cmi.2024.01.013
PMCID: PMC11043012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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