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Twin study: genotype-dependent epigenetic factors affecting free thyroxine levels in the normal range.

Epigenomics - 1 Feb 2024

Yoshioka Saki, Arakawa Yuya, Hasegawa Mika, Kato Shiho, Hashimoto Hinako, Mori Saho, Ueda Hiromichi, Watanabe Mikio

Abstract excerpt

Aim: To explore the clinical application of DNA methylation affecting thyroid function, we evaluated the association of DNA methylation with free thyroxine (FT4) and TSH measurements in monozygotic twins. Materials & methods: Discordant pairs for FT4 or TSH levels were examined for the relationship between the within-pair difference of each measurement and the DNA methylation levels using epigenome-wide...

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Identifiers

PMID: 38264851
DOI: 10.2217/epi-2023-0372

Genes

EPHB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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