Article
Discovery of Transcription Factors Involved in the Maintenance of Resident Vascular Endothelial Stem Cell Properties.
Molecular and cellular biology - 1 Jan 2024
Konishi Hirotaka, Rahmawati Fitriana N, Okamoto Naoki, Akuta Keigo, Inukai Koichi, Jia Weizhen, Muramatsu Fumitaka, Takakura Nobuyuki
Abstract excerpt
A resident vascular endothelial stem cell (VESC) population expressing CD157 has been identified recently in mice. Herein, we identified transcription factors (TFs) regulating CD157 expression in endothelial cells (ECs) that were associated with drug resistance, angiogenesis, and EC proliferation. In the first screening, we detected 20 candidate TFs through the CD157 promoter and gene expression analyses. We...
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