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Integrative Multi-omics, Network Pharmacology, Drug Sensitivity, and Docking Analyses Reveal a miR-33a-5p/HIF1A-Anchored Mechanism of Celastrol in Lung Adenocarcinoma

2026-06-11

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<title>Abstract</title> <p>Background Lung adenocarcinoma (LUAD) remains the most common histologic subtype of non-small cell lung cancer and still lacks durable, broadly effective therapeutic strategies. Celastrol is a bioactive triterpenoid with reported anti-inflammatory, anti-stress, and antitumor properties, but its integrated mechanism in LUAD remains incompletely defined. Methods Public drug-target, tran...

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Literature Corpus work
ac22cc65-bc0c-5fff-a905-343c05e1e470
DOI
10.21203/rs.3.rs-9883855/v1
Open publication

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Integrative Multi-omics, Network Pharmacology, Drug Sensitivity, and Docking Analyses Reveal a miR-33a-5p/HIF1A-Anchored Mechanism of Celastrol in Lung AdenocarcinomaDOI 10.21203/rs.3.rs-9883855/v1
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