Article
Immunogram defines four cancer-immunity cycle phenotypes with distinct clonal selection patterns across solid tumors.
Journal of translational medicine - 20 Jan 2024
Hu Ying, Sun Huaibo, Shi Wei, Chen Chen, Wu Xueying, Jiang Yu, Zhang Guoying, Li Na, Song Jin, Zhang Hao, Shen Baiyong, Zeng Hui, Zhang Henghui
Abstract excerpt
BACKGROUND: The cancer-immunity cycle (CI cycle) provides a theoretical framework to illustrate the process of the anticancer immune response. Recently, the update of the CI cycle theory emphasizes the importance of tumor's immunological phenotype. However, there is lack of immunological phenotype of pan-cancer based on CI cycle theory. METHODS: Here, we applied a visualizing method termed 'cancer immunogram' to...
Topics
- Humans
- Neoplasms
- Immunotherapy
- Phenotype
- Prognosis
- Tumor Microenvironment