Article
Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies.
Science (New York, N.Y.) - 19 Jan 2024
Martin-Alonso Carmen, Tabrizi Shervin, Xiong Kan, Blewett Timothy, Sridhar Sainetra, Crnjac Andjela, Patel Sahil, An Zhenyi, Bekdemir Ahmet, Shea Douglas, Wang Shih-Ting, Rodriguez-Aponte Sergio, Naranjo Christopher A, Rhoades Justin, Kirkpatrick Jesse D, Fleming Heather E, Amini Ava P, Golub Todd R, Love J Christopher, Bhatia Sangeeta N, Adalsteinsson Viktor A
Abstract excerpt
Liquid biopsies enable early detection and monitoring of diseases such as cancer, but their sensitivity remains limited by the scarcity of analytes such as cell-free DNA (cfDNA) in blood. Improvements to sensitivity have primarily relied on enhancing sequencing technology ex vivo. We sought to transiently augment the level of circulating tumor DNA (ctDNA) in a blood draw by attenuating its clearance in vivo. We...
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