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Article

T-cell receptor determinants of response to chemoradiation in locally-advanced HPV16-driven malignancies

2 Jan 2024

Abstract excerpt

Background: The effect of chemoradiation on the anti-cancer immune response is being increasingly acknowledged; however, its clinical implications in treatment responses are yet to be fully understood. Human papillomavirus (HPV)-driven malignancies express viral oncogenic proteins which may serve as tumor-specific antigens and represent ideal candidates for monitoring the peripheral T-cell receptor (TCR) changes...

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PMID: 38234396
DOI: 10.3389/fonc.2023.1296948

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