Article
Identification of TCR rearrangements specific for genetic alterations in EGFR-mutated non-small cell lung cancer: results from the ADJUVANT-CTONG1104 trial.
Cancer immunology, immunotherapy : CII - 1 May 2023
Chen Cunte, Liu Siyang Maggie, Chen Yedan, Ou Qiuxiang, Bao Hua, Xu Ling, Zhang Yikai, Zhang Jia-Tao, Zhong Wenzhao, Zhou Qing, Yang Xue-Ning, Shao Yang, Wu Yi-Long, Liu Si-Yang, Li Yangqiu
Abstract excerpt
Tumor response T cells, which have specific T cell receptor (TCR) rearrangements in tumor-infiltrating lymphocytes, determine their ability to interact with the mutation-derived neoantigens presented by antigen-presenting cells. Little is known about the genetic alterations related to specific TCR clones in non-small cell lung cancer (NSCLC) patients who have an epidermal growth factor receptor (EGFR) mutation....
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