Maternal plasma cortisol's effect on offspring birth weight: a Mendelian Randomisation study.

doi:10.1186/s12884-024-06250-3

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Maternal plasma cortisol's effect on offspring birth weight: a Mendelian Randomisation study.

BMC pregnancy and childbirth - 15 Jan 2024

Thompson W D, Reynolds R M, Beaumont R N, Warrington N M, Tyrrell J, Wood A R, Evans D M, McDonald T J, Hattersley A H, Freathy R M, Lawlor D A, Borges M C

Abstract excerpt

BACKGROUND: Observational studies and randomized controlled trials have found evidence that higher maternal circulating cortisol levels in pregnancy are associated with lower offspring birth weight. However, it is possible that the observational associations are due to residual confounding. METHODS: We performed two-sample Mendelian Randomisation (MR) using a single genetic variant (rs9989237) associated with...

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PMID: 38225564
DOI: 10.1186/s12884-024-06250-3
PMCID: PMC10789047

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