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Article

Persistent Salmonella infections in humans are associated with mutations in the BarA/SirA regulatory pathway.

Cell host & microbe - 10 Jan 2024

Grote Alexandra, Piscon Bar, Manson Abigail L, Adani Boaz, Cohen Helit, Livny Jonathan, Earl Ashlee M, Gal-Mor Ohad

Abstract excerpt

Several bacterial pathogens, including Salmonella enterica, can cause persistent infections in humans by mechanisms that are poorly understood. By comparing genomes of isolates longitudinally collected from 256 prolonged salmonellosis patients, we identified repeated mutations in global regulators, including the barA/sirA two-component regulatory system, across multiple patients and Salmonella serovars....

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Identifiers

PMID: 38211565
DOI: 10.1016/j.chom.2023.12.001
PMCID: PMC11410052

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