Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identifying LasR Quorum Sensors with Improved Signal Specificity by Mapping the Sequence-Function Landscape.

ACS synthetic biology - 16 Feb 2024

Zeng Min, Sarker Biprodev, Rondthaler Stephen N, Vu Vanessa, Andrews Lauren B

Abstract excerpt

Programmable intercellular signaling using components of naturally occurring quorum sensing can allow for coordinated functions to be engineered in microbial consortia. LuxR-type transcriptional regulators are widely used for this purpose and are activated by homoserine lactone (HSL) signals. However, they often suffer from imperfect molecular discrimination of structurally similar HSLs, causing misregulation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 4-Butyrolactone
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

Share to Mutation

Share to Pseudomonas aeruginosa

Share to Quorum Sensing

Share to Signal Transduction

Share to Trans-Activators

Source

Identifiers

PMID: 38206199
DOI: 10.1021/acssynbio.3c00543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identifying LasR Quorum Sensors with Improved Signal Specificity by Mapping the Sequence-Function Landscape.PMID 38206199Read ↗

Analysis of the DNA-binding domain of the <i>Pseudomonas aeruginosa</i> quorum sensing transcription factor LasRSemantic proximity Read ↗

Engineering an allosteric transcription factor to respond to new ligands.Semantic proximity Read ↗

Evolved Quorum sensing regulator, LsrR, for altered switching functions.Semantic proximity Read ↗

Quorum-sensing synthase mutations re-calibrate autoinducer concentrations in clinical isolates of Pseudomonas aeruginosa to enhance pathogenesis.Semantic proximity Read ↗

Quorum-sensing synthase mutations re-calibrate autoinducer concentrations in clinical isolates of Pseudomonas aeruginosa to enhance pathogenesisSemantic proximity Read ↗

Functional Analysis of the Quorum-Sensing Streptococcal Invasion Locus (sil)Semantic proximity Read ↗

The Distribution and Diversity of LuxI/LuxR Quorum Sensing Systems in Proteobacteria (Pseudomonadota)Semantic proximity Read ↗

Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones.Semantic proximity Read ↗

Natural genome diversity of AI-2 quorum sensing in Escherichia coli: conserved signal production but labile signal reception.Semantic proximity Read ↗

Directed Evolution of the Stringency of the LuxR Vibrio fischeri Quorum Sensor without OFF-State Selection.Semantic proximity Read ↗

Directed evolution of RhlI to generate new and increased quorum sensing signal molecule catalytic activities.Semantic proximity Read ↗

GroovDB: A database of ligand-inducible transcription factorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.