Article
Multi-omics of the gut microbial ecosystem in patients with microsatellite-instability-high gastrointestinal cancer resistant to immunotherapy.
Cell reports. Medicine - 16 Jan 2024
Cheng Siyuan, Han Zihan, Dai Die, Li Fang, Zhang Xiaotian, Lu Ming, Lu Zhihao, Wang Xicheng, Zhou Jun, Li Jian, Guo Xiaohuan, Song Panwei, Qiu Chuangzhao, Shen Wei, Zhang Qi, Zhu Ning, Wang Xi, Tan Yan, Kou Yan, Yin Xiaochen, Shen Lin, Peng Zhi
Abstract excerpt
Despite the encouraging efficacy of anti-PD-1/PD-L1 immunotherapy in microsatellite-instability-high/deficient mismatch repair (MSI-H/dMMR) advanced gastrointestinal cancer, many patients exhibit primary or acquired resistance. Using multi-omics approaches, we interrogate gut microbiome, blood metabolome, and cytokines/chemokines of patients with MSI-H/dMMR gastrointestinal cancer (N = 77) at baseline and during...
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