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Trends in cell medicine: from autologous cells to allogeneic universal-use cells for adoptive T-cell therapies

8 Jan 2024

Abstract excerpt

In currently ongoing adoptive T-cell therapies, T cells collected from patients are given back to them after ex vivo activation and expansion. In some cases, T cells are transduced with chimeric antigen receptor (CAR) or T-cell receptor (TCR) genes during the ex vivo culture period in order to endow T cells with the desired antigen specificity. Although such strategies are effective in some types of cancer, there...

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PMID: 38189591
DOI: 10.1093/intimm/dxad051

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