Fully genotyping and screening of clinically important blood-group antigens by MALDI TOF mass spectrometry.

doi:10.1002/elps.202300138

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Article

Fully genotyping and screening of clinically important blood-group antigens by MALDI TOF mass spectrometry.

Electrophoresis - 1 Mar 2024

Yang Qixiu, Li Aijing, Wang Chen, Yang Jiaxuan, Li Minghao, Zhu Huijun, Lu Daru, Zhu Ziyan, Ye Luyi

Abstract excerpt

Several molecular biology methods are available for high-throughput blood typing. In this study, we aimed to build a high-throughput blood-group genetic screening system for high-frequency blood-group antigen-negative rare-blood groups in donors and patients. The amplification primers for all blood-type gene fragments involving the selected alleles were designed for detection. Single-base extend primers were also...

Topics

Humans
Blood Group Antigens
Genotype
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Alleles
Polymorphism, Single Nucleotide
DNA Primers

Source

Open in PubMed

Identifiers

PMID: 38185764
DOI: 10.1002/elps.202300138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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