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Article

Contactin 6, A Novel Causative Gene for Congenital Hypothyroidism, Mediates Thyroid Hormone Biosynthesis Through Notch Signaling.

Thyroid : official journal of the American Thyroid Association - 1 Mar 2024

Zhang Hai-Yang, Wu Feng-Yao, Zhang Cao-Xu, Wu Chen-Yang, Cui Ren-Jie, Liu Xiao-Yu, Yang Liu, Zhang Yue, Sun Feng, Cheng Feng, Yang Rui-Meng, Song Huai-Dong, Zhao Shuang-Xia

Abstract excerpt

Background: Congenital hypothyroidism (CH) is the most common neonatal metabolic disorder. In patients with CH in China, thyroid dyshormonogenesis is more common than thyroid dysgenesis; however, the genetic causes of CH due to thyroid dyshormonogenesis remain largely unknown. Therefore, we aimed at identifying novel candidate causative genes for CH. Methods: To identify novel CH candidate genes, a total of 599...

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PMID: 38183624
DOI: 10.1089/thy.2023.0594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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