Article
Outcomes of BRCA pre-implantation genetic testing according to the parental mutation origin: a cohort study.
Reproductive biology and endocrinology : RB&E - 3 Jan 2024
Weizel Ilana, Shavit Tal, Shuli Yulia, Adler Lazarovich Chana, Halevi Rivka, Ben Ari Tal, Yaacobi-Artzi Shira, Bentov Yaakov, Feldman Baruch, Hershko Klement Anat
Abstract excerpt
BACKGROUND: The process of gamete formation and early embryonic development involves rapid DNA replication, chromosome segregation and cell division. These processes may be affected by mutations in the BRCA1/2 genes. The aim of this study was to evaluate BRCA mutation inheritance and its effect on early embryonic development according to the parental origin of the mutation. The study question was approached by...
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