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Targeting IL-17A enhances imatinib efficacy in Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia

3 Jan 2024

Abstract excerpt

Abstract Dysregulated hematopoietic niches remodeled by leukemia cells lead to imbalances in immunological mediators that support leukemogenesis and drug resistance. Targeting immune niches may ameliorate disease progression and tyrosine kinase inhibitor (TKI) resistance in Philadelphia chromosome-positive B-ALL (Ph + B-ALL). Here, we show that T helper type 17 (Th17) cells and IL-17A expression are distinctively...

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PMID: 38172124
DOI: 10.1038/s41467-023-44270-3

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