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Article

Sex-Specific Early Retinal Dysfunction in Mutant TDP-43 Transgenic Mice

19 Dec 2023

Abstract excerpt

BACKGROUND: Increasing evidence has highlighted retinal impairments in neurodegenerative diseases. Dominant mutations in TAR DNA-binding protein 43 (TDP-43) cause amyotrophic lateral sclerosis (ALS), and the accumulation of TDP-43 in the cytoplasm is a pathological hallmark of ALS, frontotemporal dementia (FTD), and many other neurodegenerative diseases. OBJECTIVE: While homozygous transgenic mice expressing the...

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PMID: 38143367
DOI: 10.3233/jad-231102

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