Article
11-deoxycortisol positively correlates with T cell immune traits in physiological conditions.
EBioMedicine - 1 Jan 2024
Peng Chunying, Jiang Xun, Jaeger Martin, van Houten Pepijn, van Herwaarden Antonius E, Koeken Valerie A C M, Moorlag Simone J C F M, Mourits Vera P, Lemmers Heidi, Dijkstra Helga, Koenen Hans J P M, Joosten Irma, van Cranenbroek Bram, Li Yang, Joosten Leo A B, Netea Mihai G, Netea-Maier Romana T, Xu Cheng-Jian
Abstract excerpt
BACKGROUND: Endogenous steroid hormones have significant effects on inflammatory and immune processes, but the immunological activities of steroidogenesis precursors remain largely unexplored. METHODS: We conducted a systematic approach to examine the association between steroid hormones profile and immune traits in a cohort of 534 healthy volunteers. Serum concentrations of steroid hormones and their precursors...
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