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Article

Inhibition of MEK Signaling Attenuates Cancer Stem Cell Activity in Anaplastic Thyroid Cancer.

Thyroid : official journal of the American Thyroid Association - 1 Apr 2024

Kimura Takahito, Doolittle Woo Kyung Lee, Kruhlak Michael, Zhao Li, Hwang Eunmi, Zhu Xuguang, Tang Binwu, Wolcott Karen M, Cheng Sheue-Yann

Abstract excerpt

Background: Anaplastic thyroid cancer (ATC) is highly aggressive and has very limited treatment options. Recent studies suggest that cancer stem cell (CSC) activity in ATC could underlie this recurrence and resistance to treatment. The recent approval by the U.S. Food and Drug Administration of the combined treatment of BRAF and MEK inhibitors for ATC patients has shown some efficacy in patients harboring the...

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Source

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Identifiers

PMID: 38115586
DOI: 10.1089/thy.2023.0521
PMCID: PMC10998707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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