Article
Salutary Response to Targeted Therapy in Anaplastic Thyroid Cancer.
Journal of investigative medicine high impact case reports - 1 Jan 2000
Fazeli Sasan, Paal Edina, Maxwell Jessica H, Burman Kenneth D, Nylen Eric S, Khosla Shikha G
Abstract excerpt
Context. Anaplastic thyroid cancer (ATC) is an aggressive tumor with a median survival of 3 to 9 months, a 1-year survival of less than 10% and without definitive therapies. Recently, in BRAF V600E mutated ATCs, new targeted therapy using a combination of a BRAF inhibitor, dabrafenib (Dab), with a mitogen-activated extracellular protein kinase (MEK) inhibitor, trametinib (Tram), has shown significant promise....
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