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HLA-based banking of induced pluripotent stem cells in Saudi Arabia

18 Dec 2023

Abstract excerpt

BACKGROUND: Human iPSCs' derivation and use in clinical studies are transforming medicine. Yet, there is a high cost and long waiting time associated with autologous iPS-based cellular therapy, and the genetic engineering of hypo-immunogenic iPS cell lines is hampered with numerous hurdles. Therefore, it is increasingly interesting to create cell stocks based on HLA haplotype distribution in a given population....

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PMID: 38111036
DOI: 10.1186/s13287-023-03612-0

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