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Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses

14 Dec 2023

Abstract excerpt

Whole-genome screens using CRISPR technologies are powerful tools to identify novel tumour suppressors as well as factors that impact responses of malignant cells to anti-cancer agents. Applying this methodology to lymphoma cells, we conducted a genome-wide screen to identify novel inhibitors of tumour expansion that are induced by the tumour suppressor TRP53. We discovered that the absence of Arrestin domain...

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PMID: 38097622
DOI: 10.1038/s41418-023-01249-3

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