Article
Electrophysiological mechanisms underlying T wave pseudonormalisation on stress ECGs in hypertrophic cardiomyopathy.
Computers in biology and medicine - 1 Feb 2024
Coleman James A, Doste Ruben, Beltrami Matteo, Coppini Raffaele, Olivotto Iacopo, Raman Betty, Bueno-Orovio Alfonso
Abstract excerpt
BACKGROUND: Pseudonormal T waves may be detected on stress electrocardiograms (ECGs) in hypertrophic cardiomyopathy (HCM). Either myocardial ischaemia or purely exercise-induced changes have been hypothesised to contribute to this phenomenon, but the precise electrophysiological mechanisms remain unknown. METHODS: Computational models of human HCM ventricles (n = 20) with apical and asymmetric septal hypertrophy...
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