Article
Patterns of Gene Expression, Splicing, and Allele-Specific Expression Vary among Macular Tissues and Clinical Stages of Age-Related Macular Degeneration.
Cells - 21 Nov 2023
Shwani Treefa, Zhang Charles, Owen Leah A, Shakoor Akbar, Vitale Albert T, Lillvis John H, Barr Julie L, Cromwell Parker, Finley Robert, Husami Nadine, Au Elizabeth, Zavala Rylee A, Graves Elijah C, Zhang Sarah X, Farkas Michael H, Ammar David A, Allison Karen M, Tawfik Amany, Sherva Richard M, Li Mingyao, Stambolian Dwight, Kim Ivana K, Farrer Lindsay A, DeAngelis Margaret M
Abstract excerpt
Age-related macular degeneration (AMD) is a leading cause of blindness, and elucidating its underlying disease mechanisms is vital to the development of appropriate therapeutics. We identified differentially expressed genes (DEGs) and differentially spliced genes (DSGs) across the clinical stages of AMD in disease-affected tissue, the macular retina pigment epithelium (RPE)/choroid and the macular neural retina...
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