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New Horizons: Translational Aspects of Osteomorphs

7 Dec 2023

Abstract excerpt

Osteomorphs are a newly described osteoclast lineage cell in mice, which are suggested to play a significant role in the maintenance of bone resorption. Preclinical investigations revealed that osteomorphs are generated through the fission of multinucleated bone-resorbing osteoclasts and can also re-fuse with existing osteoclasts. Modifications to RANKL signaling have been shown to alter cycles of fission and...

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PMID: 38060842
DOI: 10.1210/clinem/dgad711

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