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Article

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

25 Feb 2021

Abstract excerpt

Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/macrophage-derived precursors that are thought to undergo apoptosis once resorption is complete. Here, by intravital imaging, we reveal that RANKL-stimulated osteoclasts have an alternative cell fate in which they fission into daughter cells called osteomorphs. Inhibiting RANKL blocked this cellular recycling and resulted...

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PMID: 33636130
DOI: 10.1016/j.cell.2021.02.002

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