Article

Private Information Leakage from Polygenic Risk Scores

2026-02-18

Abstract excerpt

Polygenic Risk Scores (PRSs) estimate the likelihood of individuals to develop complex diseases based on their genetic variations. While their use in clinical practice and direct-to-consumer genetic testing is growing, the privacy implications of publicly sharing PRS values are often underestimated. In this work, we demonstrate that PRSs can be exploited to recover genotypes and to de-anonymize individuals. We des...

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Literature Corpus work: 2a42e190-7df2-58a7-9875-54fc3925bbdb
DOI: 10.64898/2026.02.16.706191

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